Effects of Short-Term Dietary Fiber Intervention on Gut Microbiota in Young Healthy People

Gut?microbiota are critical?to?many?aspects?of?human health including immune and metabolic health. Long-term diet influences the community structure activity of trillions microorganisms residing in human gut, but it remains unclear how gut microbiome responds to short-term intervention with dietary fiber. This study explored effects mixed fibers on gut?microbiota young, healthy people. Twelve healthy, young adults participated a randomized, crossover trial comparing polyglucan, inulin resistant malt dextrin microbiota composition bacterial abundances. During study, subjects followed their normal diets without any constraints. Microbial profiles were determined by absolute quantification 16S rRNA gene amplicon sequencing. Mixed model analysis did not reveal an effect microbial structure. At genus level, fiber for 4 days significantly promoted growth Alloprevotella, Parabacteroides Parasutterella inhibited Adlercreutzia, Anaerovorax, Enterococcus, Intestinibacter Ruminococcus 2 compared baseline. Addition whey albumen powder Corynebacterium, Collinsella, Olsenella Lactococcus interfered Megasphaera. Our results should be corroborated randomized clinical trials large sample size.